Its construction began in 1875 and was completed in 1899, and it is considered the most beautiful cathedral in northwest Mexico. 

The church has a marked Gothic influence, with two slender towers on the exterior. Inside, it has three aisles topped with beautiful altars. The decor is entirely Baroque with lavish tendencies, making it a true mosaic of styles.

The cathedral houses an organ built by the Frenchman Aristide Cavaillé-Coll, the most famous organ builder of the 19th century. Mazatlán has the distinction of being the first city in Mexico to have one of his organs.