Various cultural events, exhibitions, workshops, seminars, and congresses are held here. It has a permanent exhibition of old photographs of Los Mochis and some other figures from the country's history.

In the House of Culture, there is an archaeological collection and other historical objects from the region, as well as visual artworks by regional artists.

It features the "Mario Bojórquez" Literary Café, where in addition to enjoying a delicious coffee, a wide variety of books are available for free reading, and there is a terrace to enjoy the scenery.