It is considered a jewel of Mexican Baroque architecture, built by the Franciscans between 1689 and 1692, although the large tower was not completed until 1709 and the small tower in 1762.

Its facade is in the Baroque style and is built with quarry stone, featuring two Doric columns on each side flanking the niches where the images of San Buenaventura and San Antonio are located. The second level has four columns, and in the center, there is another niche that houses San Francisco.

Inside, valuable paintings by renowned artists Pedro López Caldera, Miguel Cabrera, and Antonio Torres can be observed.

The sacristy stands out, comprising the main altar, which displays a balanced composition, and the magnificent ship-shaped chandelier.

Next to it, the Museo Regional Potosino is housed in what used to be the Convent of San Francisco.