It was built in the second half of the 16th century, adjacent to the San Cosme and San Damián Hospital, also known as the Royal Hospital.

The idea was to build a temple where the patients could have a place to pray and attend mass.

Over the years, the temple suffered various damages from earthquakes, and shortly before the enactment of the Reform Laws, the hospital was closed and sold to private individuals in 1860.

At the end of the 19th century, the temple was in ruins, and Archbishop Gillow set out to rebuild it.

In 1945, the building came under state ownership, and the temple, which had been closed for a long time, reopened for worship.

The temple does not have an atrium, and its simple facade resembles the surrounding houses.