It was the third Dominican mission built on the Camino Real. 

The mission was completed on August 27, 1780, and the project was led by the friars Miguel Hidalgo and Joaquín Valero. 

It was established on the western edge of the San Vicente basin, with abundant water, land, and pasture. 

From its very foundation, it served as the military and administrative center of the frontier missions, intended to prevent attacks from the eastern indigenous people who descended through the San Vicente creek, as well as to protect the mountain missions.  

Of all the Dominican mission settlements, San Vicente Ferrer was the largest, covering an area of 1300 square kilometers. 

Currently, there are ruins of the mission with some standing adobe rooms without roofs, as well as a ranch located on the other side of the San Vicente canyon. 

In the Central Plaza of the town of San Vicente, there is the "Altagracia A. De Arauz" Community Museum, which displays a Cucapá house and agricultural instruments.  que muestra una de casas cucapá e instrumentos agrícolas. 

Nearby are the Petroglyphs of La Llave, a cultural manifestation of the Pai-Pai group, and the Lobera Cave, one of the largest caves on the peninsula.