It was built in 1543 and was considered the most important temple of its time. 

The facade is composed of two levels topped with an attic. The first level has a Plateresque style, and the columns with ornamentation stand out, showing a clear indigenous influence. The columns flank two niches that hold the images of the Virgin Mary and Saint Joseph. 

The interior is a Roman basilical-type ensemble with beautiful gold decorations. The main altar is made of quarry stone with gold details. 

It has a chapel dedicated to Our Lady of Health.

In front of the temple, there is a square with a fountain and green areas.