Located in the Palace of the Inquisition, a building dating back to 1736. 

This building was designed by the architect Pedro de Arrieta and served as the headquarters of the Holy Inquisition or the Tribunal of the Holy Office from 1736 to 1813. 

It is a solid and majestic construction with a Greco-Roman style portico. Above the main entrance, on the pediment, the coat of arms of the Holy Inquisition supported by two angels can be observed. 

The building had hearing rooms, a courtroom, a chapel, a secret chamber, and other rooms and chambers. 

In 1879, the architect Luis G. Anzorena added a third floor. Over time, the building has been used for various purposes: public dance venue, Military College campus, prison for political and military prisoners, and from 1847 until the middle of the 20th century, the headquarters of the National School of Medicine.

It has 24 rooms that cover topics such as embryology, displaying human fetuses; pre-Hispanic medicine with information on all the herbs that have been used for healing.

It also features a botanical garden with over 50 species and explanations of their healing properties, as well as a 19th-century pharmacy.