This Cultural Center is an elegant expression of the Baroque style and one of the most important buildings in the city. 

Formerly the College of San Francisco Xavier attached to the Temple of the Society of Jesus, it is a Jesuit construction dating back to 1660. 

Originally, it served as the headquarters of the Jesuit College of San Francisco Xavier and was one of the most innovative educational centers of its time, with astronomical observatories, a library, and laboratories. Among its professors, Francisco Xavier Clavijero, a scientist, historian, and philosopher, stands out, giving the building its name.

The building, of enormous proportions, has a two-level quarry facade. Gargoyles and ornate finials can be seen along the facade.

Inside, there is a square courtyard with a central fountain. 

The first level features an elegant cloister with semicircular arches, while the second level has a closed upper cloister with walls adorned with twenty-eight rectangular windows. 

Since 2008, it has functioned as the Clavijero Cultural Center, promoting and showcasing various cultural events. It has also hosted important exhibitions by renowned artists such as Feliciano Béjar, Francisco Toledo, and Diego Rivera, among many others.