It was not consecrated until 1730. It was elevated to the rank of cathedral in 1854 when the Diocese of San Luis Potosí was established.

This construction is located in front of Plaza de Armas, on the same site where the original parish church, a adobe hermitage with a tiled roof, stood.

The pink quarry facade is in the Baroque style, and the entrance consists of two bodies and a crown. It underwent some modifications in the early 20th century, such as the construction of the north tower, copying the south tower, and covering the cubes of both towers with quarry stone. The towers have a Baroque Solomon style and have three bodies.

The side entrance is the oldest, with a polygonal arch, and on the sides of the entrance, there are columns with Corinthian capitals. The sculptures of the apostles on the facade are made of Carrara marble, smaller copies of those found inside the Basilica of St. John Lateran in Rome.

The interior has a basilical plan, a ribbed vault adorned with vegetal motifs, moldings, and mortar medallions, a segmented dome with coffers, and a polygonal drum. The side walls have embedded Carrara marble Stations of the Cross, and there are also six lateral altarpieces and the tomb of Bishop Montes de Oca made of marble.

The main altar features a magnificent masonry cypress tree, and on its upper part, there is an image of Our Lady of Expectation, a work by Perrusquía, a famous sculptor from Queretaro. In front of the cypress tree, there is a beautiful sculpture of St. Sebastian, which is a faithful copy of the one found in the Catacombs of San Sebastian in Rome.

The choir stalls are made of carved wood, and the sacristy displays several quality paintings.

It is important to note that the interior decoration was carried out by Claudio Molina and Giuseppe Compiani, who had decorated some palaces in Russia, Constantinople, and Alexandria.