The Cathedral of Our Lady of the Immaculate Conception is an impressive Renaissance building constructed intermittently from 1575, with Francisco Becerra as the architect.

The construction continued throughout the 17th and 18th centuries. The main facade stands out for its three magnificent Baroque-style entrances. The towers were completed, the north tower in 1678 and the other in 1768, measuring 69.36 meters in height, considered the tallest in Mexico. The north tower is the only one with bells, including the renowned "La María" bell, with a diameter of 2 meters and weighing approximately eight tons.

The interior of the building is beautifully decorated with stunning artworks such as altarpieces, paintings, sculptures, exquisite ironwork, and golden veneers.

The Choir stands out, with marquetry featuring precious woods, onyx, and ivory in Mudéjar style. It also houses two organs donated by Carlos V.

The impressive Cypress, designed by Manuel Tolsá, contains bronze and silver sculptures, as well as relief work in mortar. The Altarpiece of the Kings, the Sacristy, and the Octagonal Chapel are also notable works.

Currently, on weekends, the main facade projects a videomapping show called "Puebla Mosaics," which showcases part of Puebla's history, including its gastronomy, Talavera pottery, textiles, and traditions.