Built between 1671 and 1696, its facade is in the Baroque style and is one of the most representative buildings in the city. 

Its construction was sponsored by the miners of the area and it has three entrances, a bell tower with three quarters, and a smaller one in Churrigueresque style as well.

Inside, you can admire the ancient figure of the Patroness Virgin of the City, which was a gift from King Charles I and his son Philip II of Spain in 1557, as a gesture of gratitude for the immense mining wealth of Guanajuato. The image is placed on the beautiful main altar, completely gilded, along with the images of Saint Ignatius of Loyola and the sculpture of Faith, since the original name of Guanajuato was "Real de Minas de Santa Fe" (Royal Mines of Santa Fe).

This image of the Virgin was crowned in a pontifical ceremony as the Queen of Guanajuato on May 31, 1908.

The French Baroque-style pipe organ, composed of 1,098 pipes, is also noteworthy.