The building was completed in 1585 and also served as a hospital for the religious clergy of the bishopric of Tlaxcala.

Several original elements of the temple are preserved, such as the facade, tower, and side entrance. The splendid churrigueresque facade, made of quarry stone, brick, and tile, was created between 1743 and 1767. Its three bodies are skillfully combined, presenting a flared shape that gives the church a unique character. The tile panels themselves are notable works of art.

The tower was started in 1730 and completed 37 years later. It is possibly the most slender tower in the city and consists of two square-shaped levels.

The side entrance is the oldest in Puebla. Three chapels adjoin the north wall of the church.  

The interior of the temple was modified in the 19th century. It consists of a single nave, and its ceiling, originally made of wood, now showcases ribbed vaults built during the 17th century. 

Currently, pilgrims come to venerate the remains of Blessed Sebastián de Aparicio (1520-1600). His mummified body is displayed in a glass coffin. Although this Franciscan friar has not been canonized, the people of Puebla consider him the patron saint of chauffeurs and all those who drive vehicles.

Next to the church is the Paseo de San Francisco, and nearby are the ancient public washhouses of Almoloya, as well as various places where you can taste exquisite chalupas.