It is located on the University of Sonora campus.

It features five rooms showcasing ethnographic and artisanal exhibits, as well as 10,000-year-old Yécora mummies. The collection also highlights stone instruments from the "Complejo Llano" dating back around 11,000 years.

The History section displays the arrival of the Spanish to Sonora, traditions and figures from the 19th century, the Porfiriato era, the Revolution, and the founding of the University of Sonora.