Specialized in printmaking art, it has a collection of artworks, machinery, and various objects related to printmaking.

In its six rooms, it exhibits an important collection of nearly 400 objects that belonged to José Guadalupe Posada, a Mexican engraver, illustrator, and caricaturist famous for his lithographs depicting scenes related to the Mexican folklore's perception of death.

Among the objects are tools, machinery, and various engravings.