It was founded in 1708, 54 km away from the Loreto Mission.

This mission was established by the missionary fathers Juan María de Salvatierra, Juan de Ugarte, and Julián Mayorga. The latter was responsible for the construction and remained in charge of the mission until his death on November 10, 1736. 

The location where it was established has a privileged position as it is on the edge of a small stream that runs through the Giganta Sierra.

Downstream, a few kilometers away, the missionary Juan de Ugarte established a "Visita" named San Miguel de Comondú.

Upon Father Mayorga's death, the mission and all its contents were relocated to the Mission of San Ignacio de Kada-Kaamán, and from then on it was known as "Comondú Viejo."

By the middle of the 18th century, the missionary Francisco Inamma continued with the construction of the church, which became the only one on the peninsula with three naves and therefore three altars. By 1793, when the Jesuits were expelled, the Dominicans reported the assets of the mission, stating that it had 25 religious paintings and 6 statues. 

The mission ceased to function in 1827, and currently there is no trace of the mission since in 1930, a governor ordered its dynamiting. Only the sacristy and the house where the missionary fathers lived are preserved.