The Cathedral was built in 1705 on the site where Francisco de Montejo erected the first church on October 4, 1540.

It was in March 1895, through a papal bull, that the new diocese of Campeche was established, and on July 28 of the same year, it was elevated to the status of a cathedral.

Its main attraction is its Baroque-style façade, which consists of a carved stone entrance with two stories framed by two fluted pilasters on pedestals, with the architectural ensemble standing out with its slender towers.