This museum is housed in a building constructed in 1981 by architects Teodoro González de León and Abraham Zabludovsky.

The tour takes you through rooms on different levels. They showcase over 300 works by important contemporary artists from around the world, such as Picasso, Dalí, Bacon, Magritte, Miró, and Warhol. This entire collection was donated by the artist Rufino Tamayo.

Additionally, there is a small room dedicated to displaying Mr. Tamayo's illustrations. The museum also features a café, bookstore, and documentation center.