The Regional Museum is located in the Centro Cívico 5 de Mayo, Los Fuertes.

In its four rooms, it showcases a wide collection that encompasses the country's historical evolution, starting from the origin of Native Americans, followed by the pre-Hispanic era, the viceregal period, and the ethnography of Puebla, where objects of daily life and regional dance are exhibited.

Among the museum's pieces are furniture, religious images, paintings, various pre-Hispanic artifacts, and crafts.

Additionally, it has a library.