In 1644, a masonry hermitage was built, gradually expanding until the completion of a temple dedicated to the Virgin of Guadalupe in 1650.

The temple and hospital of Our Lady of Guadalupe were blessed in 1650, and a few years later, an image of the Virgin of Guadalupe, donated by Bishop Cuevas, miraculously survived a fire.

The convent was blessed in 1707, and the chapel of Our Lady of Bethlehem in 1807.

The hospital was closed in 1820, and after the movements of the Reform Laws in 1864, it became a civil hospital.

In 1884, the complex underwent reconstruction due to damage caused by an earthquake, and this is the appearance it has maintained to this day.

At the end of the 19th century, the former convent housed the seminary college, with modern sections for physics and chemistry. It is noteworthy that one of the first X-ray machines and the first radiotelegraphic call in Latin America were installed here.

In 1916, the seminary was occupied by a military hospital, later a school, and then a barracks. Currently, the offices of the National Institute of Anthropology and History are located in the eastern part.

The temple has a single nave without a transept covered by a continuous barrel vault. Its interior stands out for its neo-Gothic decoration. 

The main cloister currently houses the 9th Pino Suárez School.