It was founded in the 17th century by Don Diego de Tapia, son of Fernando de Tapia, the founder of Querétaro. His intention was for his daughter, María Luisa, to take the habit in the order of the Clarisse nuns, for which he founded the convent.

During the colonial era, it became one of the largest and most important convents, although currently only the church and a small annex remain.

The façade features a plaque that tells the story of the temple. It showcases twin doorways, buttresses, gargoyles, rectangular windows framed in quarry stone, and a tower on the right side. The doorways have round arch entrances, and the tower has three levels and a pinnacle.

The interior is truly astonishing, with a single nave adorned with several Churrigueresque altarpieces made of carved and gilded wood. They are decorated with scrolls, cornucopias, garlands, cherubs amidst clouds, medallions, and other motifs. Behind a wrought iron grille, an antique pipe organ and a Churrigueresque altarpiece can be seen.

The temple houses a small museum with a wide variety of photographs and books about its history.