It was built between 1749 and 1752 as part of the large complex composed of the San Francisco convent and five adjoining chapels. 

This chapel is the only 18th-century temple in Guadalajara that preserves its beautiful Churrigueresque altarpieces, carved in wood. 

The main facade is Baroque in style, with a movable cornice and a niche that holds the sculpture of the Virgin of Aránzazu. 

Inside, the floor plan is a nave covered with a domed vault supported by semi-circular arches. On the side walls of the presbytery, several paintings can be observed, with the larger one on the right representing the doctrinal tree of Saint Francis of Assisi, created in the late 16th century. 

The main altar stands out with its cornices, medallions, and polychrome images. In the central niche, one can observe the admirable carving of Our Lady of Aránzazu. The side altars are ornamented in an ultra-Baroque and Churrigueresque style.

In front of the temple is the Jardín de Aránzazu, a beautiful recreational space. The area is known as "Los Dos Templos" ("The Two Temples") as the San Francisco Temple is located across the street.