The Reforma Site Museum is housed in a building dating back to the late 16th and early 17th centuries.

The building was constructed using "mucara" stone, which is coral extracted from the sea.

Throughout its history, it has had various uses. Initially, it was the Convent of San Francisco de Asís, which was distinguished by its 34-meter-tall tower that was at the seashore in those years. Later, it served as a hospital and for a long time housed the People's Library.

In 1968, it was restored and converted into the Reform Museum Site to house monuments of prominent figures from that period. It was here where President Benito Juárez promulgated the Reform Laws between 1858 and 1860, which separated the Church and the State.

The tomb of Doña Ángela Cortés y Arellano, great-granddaughter of the conqueror Hernán Cortés, who passed away on June 18, 1663, is also located here.

The museum's rooms display statues of key political figures such as Benito Juárez García and other liberals of the Reform, including Ignacio de la Llave, Miguel Lerdo de Tejada, Santos Degollado, Juan Antonio de la Fuente, Manuel Gutiérrez Zamora, Melchor Ocampo, Guillermo Prieto, and José María Mata.

It is also a space where periodic exhibitions of visual artists from the city are presented. Additionally, conferences and book presentations are held here.