This territory belonged to the Pericúes and is currently the city of La Paz.

It was founded in 1720 by the Jesuits in the place that the indigenous Guaycura people called Airapí.

The funding was provided by the Marquis of Villapuente de la Peña, José de la Puente y Peña, and from 1720 to 1728, the missionary in charge was Javier Bravo. When the mission was left, it fell into total abandonment, and it was not until two years later when Father William Gordon arrived that it was reactivated. Again, when this missionary left, it fell into oblivion again until 1736 when the missionary Segismundo Taraval took charge of the mission.

In 1749, it was decided to transfer the missionaries and natives to the Mission of Todos Santos, and since the construction was made of perishable materials, it was simply abandoned.

In the 19th century, it was decided to build a church where the mission had been, and it is the one that can be seen today.

This beautiful construction, dating from 1861, is characterized by its two towers with their pyramid-shaped tops. 

The cathedral has a clear neoclassical style on its exterior with a simple facade. 

Inside, there are beautiful Baroque altarpieces dating from the 18th century that come from some missions in Baja California.